• more effective biomedical research
• earlier breakthroughs
• faster and cheaper time to market for drug development
• improved stem cell expansion rates.

Our technology uses aligned and randomly oriented polymer nanofibers integrated into standard multi-well cell culture dishes and can be easily scaled up for larger bioreactor systems.

• facilitate high-throughput tests involving cell migration/invasion, drug discovery, stem cell expansion and directed differentiation, and in vitro diagnostics
• provide a 3-D topography that mimics the in vivo topography
• are optically transparent to allow for live-cell imaging and real time quantification of cell mobility
• have the same general size and shape of standard cell culture dishes allowing ease of acceptance and compatibility with automated systems and current equipment.

Historically, cell culture for life science research has been performed on flat, tissue culture polystyrene (TCPS) because it is cheap, optically clear, and many cells grow well on it. In reality, however, living organisms are made up of an extracellular matrix that presents both aligned physical structure and mechanical support to the cells. TCPS lacks this aligned three-dimensional (3-D) component and cells behave very differently on this flat, smooth substrate than they do in true biological settings.

Not surprisingly, drugs developed using TCPS as an in vitro substrate experience a >99% failure rate in later testing. 

Nanofiber Solutions scaffolds are engineered to mimic cellular-scale structures.  Our standard plates include polycaprolactone (PCL) nanofibers averaging less than a micron in diameter.  The fiber dimensions and specific physical properties are optimized to produce ideal synthetic in vitro models.  No other 3D cell culture product matches our ability to physically mimic the in vivo environment and create a realistic scaffold for all types of adherent cells.

We also offer specialized plates using other polymers and fiber diameters tailored for specific cell types and extracellular matrix conditions (to mimic normal, pathological, and aged ECM environments).

Compared with gels, Nanofiber Solutions synthetic scaffolds have the following benefits – they:

• do not require specialized transportation or storage
• supply a physical structure for cell adherence and growth
• allow for easy cell extraction for gene and protein analyses
• are sold in standard cell culture plate sizes and thus are adaptable for automation
• do not introduce a third-party animal contaminant in stem cell use.